GATA binding protein 3: the autism perspective
نویسندگان
چکیده
منابع مشابه
GATA binding protein 3 overexpression and suppression significantly contribute to the regulation of allergic skin inflammation.
GATA binding protein 3 (GATA3) is a key molecule regulating the balance in the ratio of type 1 helper T (Th1) cells to type 2 helper T (Th2) cells, which is thought to be indicative of the pathogenesis of allergic diseases such as asthma and atopic dermatitis. The aim of this study was to investigate the role of GATA3 in allergic skin inflammation. Transgenic (Tg) mice overexpressing human GATA...
متن کاملCoordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR.
The posttranscriptional mechanisms whereby RNA-binding proteins (RBPs) regulate T cell differentiation remain unclear. RBPs can coordinately regulate the expression of functionally related genes via binding to shared regulatory sequences, such as the adenylate-uridylate-rich elements (AREs) present in the 3' untranslated region (UTR) of mRNA. The RBP HuR posttranscriptionally regulates IL-4, IL...
متن کاملGATA binding protein 3 is correlated with leptin regulation of PPARγ1 in hepatic stellate cells
Accumulating evidence reveals that hormone leptin, mainly produced by adipocyte, plays a unique role in promotion of liver fibrosis. Hepatic stellate cell (HSC) activation is a key step in liver fibrosis and peroxisome-proliferator activated receptor γ (PPARγ) exerts a crucial role in inhibition of HSC activation. Our previous researches demonstrated that leptin reduced PPARγ1 (a major subtype ...
متن کاملMolecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility
BACKGROUND Diabetic cardiomyopathy, a diabetes-specific complication, refers to a disorder that eventually leads to left ventricular hypertrophy in addition to diastolic and systolic dysfunction. In recent studies, hyperglycemia-induced reactive oxygen species (ROS) in cardiomyocytes have been linked to diabetic cardiomyopathy. GATA binding protein 4 (GATA-4) regulates the expression of many ca...
متن کاملThe N-terminal fingers of chicken GATA-2 and GATA-3 are independent sequence-specific DNA binding domains.
The GATA family of vertebrate DNA binding regulatory proteins are expressed in diverse tissues and at different times of development. However, the DNA binding regions of these proteins possess considerable homology and recognize a rather similar range of DNA sequence motifs. DNA binding is mediated through two domains, each containing a zinc finger. Previous results have led to the conclusion t...
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ژورنال
عنوان ژورنال: OA Medical Hypothesis
سال: 2013
ISSN: 2053-0781
DOI: 10.13172/2053-0781-1-1-501